There are three drugs which accord to this class, acarbose, miglitol and voglibose, of which voglibose is the newest. Voglibose array over both acarbose and miglitol in agreement of ancillary aftereffect profile. But acarbose has an bend over voglibose in agreement of ability (FPG, PPHG, HBA1c).There are several trials acknowledging the use of voglibose in the administration of PPHG. Also, it has been accustomed that it is PPHG, not FPG, which is the brand of cardiovascular disorders associated with diabetes. So, authoritative PPHG is acute and voglibose is adumbrated for the administration of PPHG.
Voglibose marketed in India as "Prevog" by Zydus Cadila.We performed a randomized crossover accessible allusive abstraction to appraise the ability and assurance of voglibose and acarbose in 30 patients with blazon 2 diabetes who were not able-bodied controlled with diet therapy. There was no cogent abridgement of FBG with either voglibose or acarbose at 4 and 8 weeks afterwards treatment. In adverse to voglibose, analysis with acarbose decidedly decreased the 2 h PPBG at 4 and 8 weeks and the 2 h postprandial serum insulin assimilation at 8 weeks. Adverse biologic contest were added frequently appear in acarbose-treated patients (P<0.05). Increased flatulence was empiric in 56.7 and 90% of the patients demography voglibose and acarbose, respectively, while belly appendage was acclaimed in 10 and 16.7%. Decidedly decreased physique weights of 0.9 and 0.8 kg were recorded at 8 weeks afterwards voglibose and acarbose therapy, respectively. We achieve that both voglibose (0.2 mg) and acarbose (100 mg) thrice circadian decidedly decreased HbA(1c), PPBG and postprandial insulin levels. At these dosage levels, voglibose was associated with beneath gastrointestinal ancillary furnishings and hardly beneath ability for postprandial glucose reduction.Voglibose is an alpha-glucosidase inhibitor acclimated for blurred post-prandial claret glucose levels in humans with diabetes mellitus. Voglibose delays the assimilation of glucose thereby reduces the accident of macrovascular complications.