Entecavir is a nucleoside analog (more specifically, a guanosine analogue) that inhibits about-face transcription, DNA archetype and archetype in the viral archetype process. The drug's architect claims that entecavir is added alive than antecedent agents acclimated to amusement hepatitis B (lamivudine and adefovir).
The abstraction evaluated nucleoside-naïve patients from two Phase III entecavir studies -- hepatitis B e antigen (HBeAg)-positive and HBeAg-negative -- who afterwards entered an open-label rollover abstraction and accustomed entecavir for a absolute continuance of at atomic 3 years. HBeAg is begin in serum during astute and abiding HBV infection and indicates that the virus is replicating and the adulterated being has top levels of HBV DNA.
During the Phase III program, patients accustomed an entecavir dosage of 0.5 mg circadian and during the abiding rollover study, all patients accustomed 1.0 mg of entecavir daily. Some patients accustomed circumstantial lamivudine (100 mg daily) for a abrupt aeon of time aboriginal in the rollover abstraction afore continuing on entecavir monotherapy (1.0 mg daily) afterwards the agreement was amended.
Entecavir was accustomed by the U.S.FDA in March 2005.
Entecavir is a almighty HBV antiviral biologic that in antecedent trials has accustomed above virologic, histologic and biochemical outcomes in nucleoside-naïve patients afterwards analysis periods alignment from 48 weeks to 3 years, with basal actualization of resistance. The present abstraction confirms these results. Entecavir is a cyclopentyl deoxyguanosine analog that was accustomed for the analysis of the hepatitis B virus (HBV) in 2005. In Phase III trials, it showed almighty HBV abolishment with drops of 6- to 7-log copies/mL in HBV DNA at 1 year. In addition, ante of genotypic attrition in nucleos(t)ide-naïve patients are low, extensive alone 1.2% afterwards 6 years. Safety and ability accept been accustomed in compensated cirrhosis and HIV-coinfected patients. Studies in decompensated cirrhosis aswell appearance efficacy. Because of almighty viral abolishment and a ample abiogenetic barrier to resistance, entecavir is now a first-line best in a lot of HBV analysis guidelines and has become an basic allotment of the HBV analysis armamentarium.
USES Entecavir is acclimated to amusement abiding hepatitis B. It aswell helps anticipate the hepatitis B virus from adding and infecting new alarmist cells. Entecavir is aswell adumbrated for the analysis of abiding hepatitis B in adults with HIV/AIDS infection. However, entecavir is not alive adjoin HIV.