Caspofungin
Side effects
Compared to amphotericin B, caspofungin seems to acquire a about low blow of accessory effects. In analytic studies and postmarketing reports, the accessory accoutrement credible in 1% or added of the patients were as follows:
Gastrointestinal system: nausea, vomiting, abdomen pain, and diarrhea
Central abashed system: headache
Whole body: fever, phlebitis or thrombophlebitis, complications at the intravenous cannulation website (e.g. induration), bearding pain, flu-like syndrome, myalgia, chills, and paresthesia
Respiratory: dyspnea
Renal: added claret creatinine
Hematological: anemia
Electrolytes: hypokalemia
Liver: added alarmist enzymes (asymptomatic)
Hypersensitivity: rash, facial edema, pruritus
Other: tachycardia
Additionally, aberrant cases of adapted alarmist damage, ambiguous edema and swelling, and hypercalcemia acquire been seen. One case of anaphylaxis (severe allergic reaction) has aswell been noted.
Drug interactions
Cyclosporine: see below Hepatic effects
Tacrolimus: abeyant pharmacokinetic interactions
Other systemic antimycotic agents: with amphotericin B, itraconazole and mycophenolate, no interactions acquire been seen
Inducers of biologic approval (e.g. carbamazepine, phenytoin, rifampin, dexamethason): accept 70 mg i.v. as aliment dosage instead of 50 mg
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