Entecavir INN , abbreviated ETV, is an clear antiviral biologic acclimated in the assay of hepatitis B infection. It is marketed below the bargain names Baraclude (BMS) and Entaliv (DRL).
Entecavir is a nucleoside analog (more specifically, a guanosine analogue) that inhibits changeabout transcription, DNA classic and classic in the viral classic process. The drug's artist claims that entecavir is added animate than anterior agents acclimated to activity hepatitis B (lamivudine and adefovir).
Entecavir was acclimatized by the U.S.FDA in March 2005.
USES Entecavir is acclimated to activity constant hepatitis B. It aswell helps ahead the hepatitis B virus from abacus and infecting new alarmist cells. Entecavir is aswell adumbrated for the assay of constant hepatitis B in adults with HIV/AIDS infection. However, entecavir is not animate abut HIV.
Clinical Trials
The analytic adeptness of entecavir has been brash in several randomized, double-blind, multicentre trials. Clear entecavir was an able and about able adequate treatment.
History
1992: SQ-34676 at Squibb as allocation of anti-herpes virus program
1997: BMS 200475 developed at BMS biologic assay assemblage as antiviral nucleoside alternation à Activity accustomed abut HBV, HSV-1, HCMV, VZV in corpuscle ambit & no or little activity abut HIV or influenza
Superior activity empiric abut HBV pushed assay arise BMS 200475, its base analogues and its enantiomer abut HBV in HepG2.2.15 corpuscle line
Comparison to added NAs, authentic added accurate absolute inhibitor of HBV by advantage of accepting Guanine NA
1998: Inhibition of hepadnaviral polymerases was accustomed in vitro in apologue to a bulk of NAs-TP
Metabolic studies showed added able phosphorylation to triphosphate animate form
3 year assay of woodchuck archetypal of CHB à constant antiviral adeptness and constant activity spans afterwards credible accomplishment of resistance
Efficacy # LVD advancing HBV classic in vitro
Superior activity compared to LVD invivo for both HBeAg + & HBeAg- patients
Efficacy in LVD adverse CHB patients
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