What is rifampicin
Rifampicin is also known as rifaldazine, R / AMP, rofact (in Canada), and rifampin in the United States. There are various types of rifamycins from which this is derived, but the rifampicin form, with a 4-methyl-1-piperazinaminyl group, is by far the most clinically effective.
Rifampicin is an intensely red solid, and the small fraction which reaches body fluids is known for imparting a harmless red-orange color to the urine (and to a lesser extent, also sweat and tears) of users, for a few hours after a dose . Maximal concentrations in the blood are decreased by about a third when the antibiotic is taken with food. [4]
Rifampicin is used in the treatment of a number of bacteria, but best known for activity against Mycobacterium strains, such as cause tuberculosis and Hansen's Disease. Rifampicin can be used as monotherapy for a few days as prophylaxis against meningitis, but resistance develops quickly during long treatment of active infections, so the drug is always used against active infections in combination with other antibiotics.
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