The Use of Cefaclor

Cefaclor is a second-generation oral cephalosporin, for a variety of Gram-positive bacteria and gram-negative bacteria have a strong role in the killing. This product is broad-spectrum semi-synthetic cephalosporin antibiotics. Of penicillinase-producing Staphylococcus aureus, A group hemolytic streptococcus, Streptococcus viridans and Staphylococcus epidermidis cefadroxil activity and the same, do not produce the enzyme Staphylococcus aureus and pneumococcus compared the antibacterial effect of cefadroxil 2 to 4 times stronger. Against Gram-negative bacteria including Escherichia coli and Klebsiella pneumoniae stronger activity than cephalexin, and cefadroxil is similar, the Proteus mirabilis, Salmonella and Shigella activity stronger than cefadroxil . 2.9 ~ 8mg / L of the product can suppress all of Haemophilus influenzae, including ampicillin-resistant strains.
Properties
The product is film-coated tablets, except after significant white coating to slightly yellow, or white, white or slightly yellow powder or crystalline powder; micro odorless, bitter taste. The materials in water slightly soluble in methanol, ethanol, chloroform or dichloromethane is almost insoluble. Than the rotation to take the goods, accurately weighed, dissolved in water and diluted to 1ml contains 4mg of each solution, according to measurement, optical rotation of +105 ° to +120 °. Absorption coefficient of the product, accurately weighed, dissolved in water and diluted per 1ml solution containing about 20μg, according to spectrophotometry, the wavelength at 264nm absorbance, absorption coefficient (E1% 1cm) 230 to 255 .
Indications
Used in clinical infections caused by susceptible strains of the following: 1. Respiratory tract infections: such as pharyngitis, tonsillitis, bronchitis, pneumonia by the pneumococcus, Haemophilus influenzae, Streptococcus pyogenes (A group of β-hemolytic streptococcus ) and Moraxella catarrhalis coli cause. 2 Ear, Nose Section infections: such as otitis media by the Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes (A group of β-hemolytic streptococcus), and Moraxella catarrhalis coli cause. 3 urinary tract infections: such as pyelonephritis, cystitis caused by E. coli, Proteus mirabilis, cefaclor capsules
Klebsiella spp and coagulase-negative staphylococci. 4 skin and soft tissue infections: such as cellulitis, boils, skin abscesses, folliculitis, mastitis, etc. by the Staphylococcus aureus and Streptococcus pyogenes (A group of β-hemolytic streptococcus) cause. 5 Other: sty, periodontal inflammation, pericoronitis, jaw inflammation, scarlet fever, etc.
Drug interactions
Furosemide, by Thani acid, bumetanide and other strong diuretic drugs, carmustine, streptozocin, and aminoglycoside antibiotics, such as anticancer drugs such as renal toxicity of the product combined with an increase in the possibility of renal toxicity.
Clavulanic acid can enhance some of the goods produced by β-lactamase and the materials resistant gram-negative bacilli antimicrobial activity.
Enable the products of oral probenecid plasma concentration levels and delayed excretion of the product.
Contraindications
Some patients may have cross-allergy to penicillin. Cephalosporin allergy caution on renal function with mild dysfunction, according to the original dose can be administered, moderate and severe renal function decline in patients with doses of normal doses of 1 / 2 and 1 / 4. Meal served to reduce absorption, should be an empty stomach. The goods through the placenta, pregnant women should not use.
Note
The goods and penicillins or cephamycin (Cephamycin) are cross-allergic reactions, so to penicillins, penicillin derivatives, penicillamine, and cephamycin allergy caution.
Liver dysfunction with caution.
Severe renal insufficiency or completely noninvasive, using this product should be blood concentration monitoring.
Have a history of gastrointestinal disease, particularly ulcerative colitis, enteritis, or antibiotic-associated colitis with caution. 5. Long-term use of the product can cause flora, causing secondary infections.
Laboratory indicators of interference: anti-globulin (Coombs) test may be positive; copper sulfate urine sugar tests can show false positive, but the enzyme glucose test method is not affected; serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and blood urea nitrogen can be increased; using Jaffe reaction for determination of serum and urine creatinine values ​​may have a false increase.
The product should be fasting oral, food does not affect the total absorption of the product, but may slightly delay the peak time, lower peak concentration. Milk does not affect the absorption of the product.
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