Gestrinone adverse effects

Like danazol, many of gestrinone's adverse effects are due to its androgenic activity. These include acne, seborrhoea, hirsutism, weight gain and changes to the voice. Most patients will have at least one adverse event. Although gestrinone inhibits ovulation, patients need to use barrier contraception while taking the drug. This is because the drug is embryotoxic in some animals and can cause masculinisation of a female fetus. Gestrinone also significantly reduces HDL concentrations.